Epigenetics and Missing Heredity
Vol.1,No.2(2010)
The best working definition for the epigenetics is that it is the study of traits heritable through meiosis or mitosis that are not dependent on the primary DNA sequence. Even so, British geneticist Adrian Bird has commented: “Epigenetics is useful word if you don’t know what’s going on – if you do, you use something else” (Anonymus 2010).
DNA methylation; histone modifications; noncoding RNA; agouti gene; winter hunger
Anonymus (2010): Making a Mark. Nature Biotechnology, 28, 1031. DOI: http://dx.doi.org/10.1038/nbt1010-1031">10.1038/nbt1010-1031
Fox Keller, E. (2010): Goodbye, Nature vs Nurture. New Scientist, 2778, 28–29. DOI: http://dx.doi.org/10.1016/S0262-4079%2810%2962277-4">10.1016/S0262-4079(10)62277-4
Jablonka, Eva – Lamb, Marion J. (1995): Epigenetic Inheritance and Evolution: The Lamarckian Dimension. Oxford – New York: Oxford University Press.
Jablonka, Eva – Lamb, Marion J. (2005): Evolution in Four Dimensions. Cambridge, MA: The Mit Press.
Jones, P. A. – Baylin, B. S. (2002): The Fundamental Role of Epigenetic Events in Cancer. Nature Reviews Genetics, 3, 415–428.
Lu, Q. et al. (2006): Epigenetics, Disease, and Therapeutic Interventions. Ageing Research Reviews, 5, 449–467. DOI: http://dx.doi.org/10.1016/j.arr.2006.07.001">10.1016/j.arr.2006.07.001
Lyko, F. – Brown, R. (2005): DNA Methyltransferase Inhibitors and the Development of Epigenetic Cancer Therapies. Journal of National Cancer Institute, 97, 1498–1506. DOI: http://dx.doi.org/10.1093/jnci/dji311">10.1093/jnci/dji311
Ng, S.-F. et al. (2010): Chronic High-fat Diet in Fathers Programs β-cell Dysfunction in Female Rat Offspring. Nature, 467, 963–966. DOI: http://dx.doi.org/10.1038/nature09491">10.1038/nature09491
Reik, W. et al. (2001): Epigenetic Reprogramming in Mammalian Development. Science, 293, 1089–1093. DOI: http://dx.doi.org/10.1126/science.1063443">10.1126/science.1063443
Weaver, I. C. G. et al. (2004): Epigenetic Programming by Maternal Behavior. Nature Neuroscience, 7, 847–854. DOI: http://dx.doi.org/10.1038/nn1276">10.1038/nn1276
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