Lidská fertilizace in vitro: Nenaplněné obavy a neočekávané výhody
Roč.1,č.1(2010)
Za tři desetiletí se technika in vitro oplození proměnila z oboru, v který věřil jen málokdo, na techniku, která je pevnou součástí moderní medicíny. Obavy, které s ní byly spojovány, se nenaplnily. Naopak, in vitro oplození našlo uplatnění i tam, kde to nikdo nepředpokládal. V kombinaci s předimplantační genetickou diagnostikou se využívá jako prevence dědičných onemocnění. Potřeba oplození in vitro se ukázala i v zemích třetího světa, které se potýkají s důsledky populační exploze.
V současnosti se rozvíjejí nové biotechnologie, které narážejí na odpor veřejnosti. Historie se opakuje. Jsou zdůrazňovány především jejich možná i ryze hypotetická rizika a mnohé jejich budoucí přínosy nejsou a za současného stavu poznání ani nemohou být předvídány.
Rozvoj in vitro oplození nabízí lekci pro hodnocení nastupujících biotechnologií. Jejich výrazné omezení nebo dokonce zákaz by zjevně znamenaly pro budoucnost lidstva závažná omezení.
biotechnologie; bioetika; IVF; rizika a přínosy
Radko Rajmon
Czech University of Life Sciences in Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic
Rajmon, Radko (born 1968 in Ústí nad Orlicí, Czech Republic)
He graduated at Veterinary and Farmaceutical University Brno. He
is interested in the topics of animal reproduction and the effects of
some environmental substances on it. He works as an associated professor at the Department of Veterinary Sciences, Czech University of Life Sciences in Prague.
Miroslava Krejčová
Czech University of Life Sciences in Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic
Krejčová, Miroslava (born 1983 in Prague, Czech Republic)
She graduated at Czech University of Life Science in Prague. Nowadays
she is Ph.D student at Department of Veterinary Sciences. She is
interested in the biotechnology in the reproduction of farm animals
and is participant in a teaching of the anatomy of farm animal.
Jaroslav Petr
Institute of Animal Science, Prague, Czech Republic
Petr, Jaroslav (born 1958 in Kolín, Czech Republic)
He graduated from the Agricultural University, Prague. He works at
the Institute of Animal Science, Prague, where he is engaged in the
study of animal reproduction, especially in studies of mammalian
oocytes. He is a Professor at the Czech University of Life Sciences
in Prague.
Abbott, A. (2010): Baby boom bags Nobel prize. Nature, 467, 641–642. https://doi.org/10.1038/467641a
Baslington, H. (1996): Anxiety overflow: Implications of the IVF surrogacy case and the ethical and moral limits of reproductive technologies in Britain. Women’s Studies International Forum, 19, 675–684. https://doi.org/10.1016/S0277-5395(96)00088-X
Borini, A. – Bafaro, G. – Violini, F. – Bianchi, L. – Casadio, V. – Flamigni, C. (1995): Pregnancies in postmenopausal women over 50 years old in an oocyte donation program. Fertility and Sterility, 63, 258–262.
Calvert, J. (2008): The commodification of emergence: Systems biology, synthetic biology and intellectual property. Biosocieties, 3, 383–398. https://doi.org/10.1017/S1745855208006303
Davis, D. A. (2009): The politics of reproduction: The troubling case of Nadya Suleman and assisted reproductive technology. Transforming Antropology, 17, 105–116. https://doi.org/10.1111/j.1548-7466.2009.01061.x
Davis, D. S. (1997): Genetic dilemmas and the child’s right to an open future. The Hastings Center Report, 27, 7–15.
Edwards, R. G. – Bavister, B. D. – Steptoe, P. C. (1969): Early stage of fertilization in vitro in human oocytes matured in vitro. Nature, 221, 632–635. https://doi.org/10.1038/221632a0
Fishel, S. – Green, S. – Hunter, A. – Lisi, F. – Rinaldi, L. – Lisi, R. – McDermott, H. (1997): Human fertilization with round and elongated spermatids. Human Reproduction, 12, 336–340. https://doi.org/10.1093/humrep/12.2.336
Frith, L. (2001): Gamete donation and anonymity. The ethical and legal debate. Human Reproduction, 16, 818–824. https://doi.org/10.1093/humrep/16.5.818
Gaskell, G. – Allum, N. – Bauer, M. – Durant, J. – Allansdottir, A. – Bonfadelli, H. – Boy, B. – de Cheveigné, S. – Fjaestad, B. – Gutteling, J. M.– Hampel, J. – Jelsøe, E. – Jesuito, J. C. – Kohring, M. – Kronberger, N. – Midden, C. – Nielsen, T. H. – Przestalski, A. – Rudanem, T. – Sakellaris, G. – Torgersen, H. – Twardowski, T. – Wagner, W. (2000): Biotechnology and the European public. Nature Biotechnology, 18, 935–938. https://doi.org/10.1038/79403
Geron Corporation (2010): Geron initiates clinical trial on human embryonic stem cell-based therapy. First patient treated atShepherdCenterinAtlanta. http://www.geron.com/investors/factsheet/pressview.aspx?id=1235
Handyside, A. H. – Kontogianni, E. H. – Hardy, K. – Winston, R. M. (1990): Pregnacies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature, 344, 768–770. https://doi.org/10.1038/344768a0
Janssens, P. M. W. – Simons, A. H. M. – van Kooii, R. J. – Blokzijl, E. – Dunselman, G. A. J. (2006): A new Dutch Law regulating provision of identifying information of donors to offspring: Background, content and impact. Human Reproduction, 21, 852–856. https://doi.org/10.1093/humrep/dei407
Johnson, M. H. – Franklin S. B. – Cottingham, M. – Hopwood, N. (2010): Why Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Human Reproduction, 25, 2157–2174. https://doi.org/10.1093/humrep/deq155
Hanmer, J. (1987): Reproduction trends and the emergence of moral panic. Social Science and Medicine, 25, 697–704. https://doi.org/10.1016/0277-9536(87)90097-9
Lane, H. L. (2002): Do deaf people have disability. Sign Language Studies, 2, 356–379. DOI: https://doi.org/10.1353/sls.2002.0019
Lartigue, C. – Vashee, S. – Algire, M. A. – Chuang, R.-Y. – Benders, G. A. – Ma, L. – Noskov, V. N. – Denisova, E. A. – Gibbon, D. G. – Assad-Garcia, N. – Alperovich, N. – Thomas, D. W. – Merryman, C. – Hutchison, C. A. – Smith, H. O. – Venter, J. C. – Glass, J. I. (2009): Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast. Science, 325, 1693–1696. https://doi.org/10.1126/science.1173759
Mies, M. (1985): ‘Why do we need all this?’ A call against genetic engineering and reproductive technology. Women’s Studies International Forum, 8, 553–560.
Moreno, J. D. – Nolan, J. M.– Samad, E. U. – Martins, S. A. – Brozak, S. G. – Taylor, P. L. (2010): Long shadow of the stem-cell rulling. Nature, 467, 1031–1033. https://doi.org/10.1038/4671031a
Murray, C. – Golombok, S. (2000): Oocyte and semen donation: A survey of UKlicensed centres. Human Reproduction, 15, 2133–2139. https://doi.org/10.1093/humrep/15.10.2133
Nobel Assembly at Karolinska Institutet (2010): The Nobel Prize in Physiology or Medicine 2010 Robert G. Edwards, Press Release http://nobelprize.org/nobel_prizes/medicine/laureates/2010/press.html
Ombelet, W. (2007): Affordable IVF for developing countries. Reproductive BioMedicine Online, 15, 257–265. https://doi.org/10.1016/S1472-6483(10)60337-9
Ory, S. (2010): The American octuplet experience: A transformative event. Fertility and Sterility, 93, 337–338. https://doi.org/10.1016/j.fertnstert.2009.12.011
Palermo, G. – Joris, H. – Derde, M. P. – Camus, M. – Devroey, P. – Van Steirteghem, A. C. (1993): Sperm characterization and outcome of human assisted fertilization by subzonal insemination and intracytoplasmic sperm injection. Fertility and Sterility, 59, 826–835.
Poster, R. A. (1989): The ethics and economics of enforcing contracts of surrogate motherhood. Journal of Contemporary Health Law and Policy, 5, 21–31.
Rosenthal, M. S. (2010): A preventive ethics approach to IVF in the age of octuplets. Fertility and Sterility, 93, 339–340. https://doi.org/10.1016/j.fertnstert.2009.12.010
Schenker, J. G. (2005): Assisted reproduction practice: Religious perspectives. Reproductive BioMedicine Online, 10, 310–319. https://doi.org/10.1016/S1472-6483(10)61789-0
Smajdor, A. (2007): Deciding the fate of disputed embryos: Ethical issues in the case of Natallie Evans. Journal of Experimental & Clinical Assisted Reproduction, 4, 2. https://doi.org/10.1186/1743-1050-4-2
Sozou, P. D. – Sheldon, S. – Hartshorne, G. M. (2010): Consent agreements for cryopreserved embryos: The case for choice. Journal of Medical Ethics, 36, 230–233. https://doi.org/10.1136/jme.2009.033373
Steptoe, P. C. – Edwards, R. G. (1978): Birth after the preimplantation of a human embryo. Lancet, 2, 366. https://doi.org/10.1016/S0140-6736(78)92957-4
Steptoe, P. C. – Edwards, R. G. – Purdy, J. M.(1971): Human blastocyst grown in culture. Nature, 229, 132–133.
Thomson, J. A. – Itskovitz-Eldor, J. – Shapiro S. S. – Waknitz M. A. – Swiergiel, J. J. – Marshall, V. S. – Jones, J. M.(1998): Embryonic stem cell lines derived from human blastocysts. Science, 282, 1145–1147.
Trewavas, A. J. – Leaver, C. J. (2001): Is opposition to GM crops science or politics? EMBO reports, 2, 455–459. https://doi.org/10.1093/embo-reports/kve123
Trounson, A. – Mohr. L. (1983): Human pregnancy following cryopreservation thawing and transfer of eight-cell embryo. Nature, 305, 707–709. https://doi.org/10.1038/305707a0
Van Niekerk, A. – van Zyl, L. (1995): The ethics of surrogacy: Women’s reproductive labour. Journal of Medical Ethics, 21, 345–349. https://doi.org/10.1136/jme.21.6.345
Van Voorhis, B. J. – Grinstead, D. M. – Sparks, A. M. T. – Gerard, J. L. – Weir, R. F. (1999): Establishment of a successful donor embryo program: Medical, ethical, and policy issues. Fertility and Sterility, 71, 604–608. https://doi.org/10.1016/S0015-0282(98)00545-7
Copyright © 2014 Radko Rajmon, Miroslava Krejčová, Jaroslav Petr