Antiviral activity of Deschampsia antarctica plant extracts in vitro
Vol.13,No.2(2023)
Main objective of research to study the D. antarctica extracts antiviral activity which was grown in vitro and propagated by cloning. The D. antarctica aqueous ethanolic extracts was tested on in vitro models of MDСK – Madin-Darby Canine Kidney cells and PEK – Porcine Embryonic Kidney cells and influenza virus, А/FM/1/47(H1N1) strain and transmissible gastroenteritis virus – porcine coronavirus (TGEV). The antiviral activity of D. antarctica plant extracts (G/D9-1 genotype) on experimental models of influenza viruses and Coronavirus TGEV in vitro was conducted. D. antarctica plant extracts high antiviral activity on influenza viruses and Coronavirus TGEV in vitro was shown.
Deschampsia antarctica extracts; antiviral activity; polyphenolic compounds; flavonoids
Akram, M., Mahmood, I., Tahir, S., Shah, M. A., Mahmood, Z., Altaf, A., Ahmad, K., Munir, N., Daniyal, M., Nasir, S. and Mehboob, H. (2018): Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytotherapy Research, 32(5): 811-822. doi: 10.1002/ptr.6024
Badshah, S. L., Faisal, S., Muhammad, A., Poulson, B. G., Emwas, A. H. and Jaremko, M. (2021): Antiviral activities of Flavonoids. Biomedicine & Pharmacotherapy, 140: 111596. doi: 10.1016/j.biopha.2021.111596
Chojnacka, K., Skrzypczak, D., Izydorczyk, G., Mikula, K., Szopa, D. and Witek-Krowiak, A. (2021): Antiviral properties of polyphenols from plants. Foods, 10: 2277. doi: 10.3390/foods10102277
Dai, W., Bi, J., Li, F., Wang, S., Huang, X., Meng, X., Sun, B., Wang, D., Kong, W. and Jiang, C. J. V. (2019): Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn mice. Viruses, 11(7): 25. doi: 10.3390/v11070625
Galkin, N. A., Arkcypova, M., Starosyla, D., Deriabin, O., Vasylchenko, O., Rybalko, S. and Golembiovska, O. (2023): Antiviral activity of original flavonoids-containing phytopreparation against human alphaherpesvirus2, hepatitis C surrogatevirus and transmissible gastroenteritis coronavirus. Farmacia, 71(5): 991-1000. doi: 10.31925/farmacia.2023.5.14
Gidekel, M., Weber, H., Cabrera, G., Gutierres, A., Osorio, J., Becera, J., Podhajcer, O., Cafferata, E., Sunkel, C. and Mihovilovic, I. (2011): Extracts of Deschampsia antarctica Desv. with antineoplastic activity. Pat. US 2011/0177178 A1, Appl. No. 12/928317
Ivannikov, R., Laguta, I., Anishchenko, V., Skorochod, I., Kuzema, P., Stavinskaya, O., Parnikoza, I., Poronnik, O., Myryuta, G. and Kunakh, V. (2021): Composition and radical scavenging activity of the extracts from Deschampsia antarctica E. Desv. plants grown in situ and in vitro. Chemistry Journal of Moldova, 16: 105-114. doi: 10.19261/cjm.2021.841
Köhler, H., Contreras, R. A., Pizarro, M., Cortés Antíquera, R. and Zúñiga, G. E. (2017): Antioxidant responses induced by UVB radiation in Deschampsia antarctica Desv. Frontiers in Plant Science, 8: 921. doi: 10.3389/fpls.2017.00921
Kunakh, V. A., Twardovska, M. O., Andreev, I. O., Drobyk, N. V., Navrotska, D. O., Nuzhyna, N., Poronnik, O. O., Konvalyuk, I. I., Ivannikov, R.V. and Parnikoza, I. Yu. (2023): Composition and antioxidant properties of plant extracts from Antarctica vascular plants (Deschampsia antarctica E. Desv.) Polish Polar Research, 44(1): 41-68. doi: 10.24425/ppr.2023.144537
Ryu, Y. B., Jeong, H. J., Kim, J. H., Kim, Y. M., Park, J.-Y., Kim, D., Naguyen, T. T. H., Park, S.-J., Chang, J. S. and Park, K. H. J. B. (2010): Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. Bioorganic & Medicinal Chemistry, 18(22): 7940-7947. doi: 10.1016/j.bmc.2010.09.035
Shibata, C., Ohno, M., Otsuka, M., Kishikawa, T., Goto, K., Muroyama, R., Kato, N., Yoshikawa, T., Takata, A. and Koike, K. J. V. (2014): The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. Virology, 462: 42-48. doi: 10.1016/j.virol.2014.05.024
Xu, L., Su, W., Jin, J., Chen, J., Li, X., Zhang, X., Sun, M., Sun, S., Fan, P., An, D., Zhang, H., Zhang, X., Kong, W., Ma, T. and Jiang, C. (2014): Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. Viruses, 6(7): 2778-2795. doi: 10.3390/v6072778
Zhang, W., Qiao, H., Lv, Y., Wang, J., Chen, X., Hou, Y., Tan, R. and Li, E. (2014): Apigenin inhibits enterovirus-71 Infection by disrupting viral RNA association with transacting factors. PLoS One, 9(10): 110429. doi: 10.1371/journal.pone.0110429
Web sources / Other sources
[1] Preclinical studies of medicinal products (methodological recommendations), 2001. Edited by O.V. Stefanov. Kyiv: Avicenna. 528 p. (In Ukraine).
Copyright © 2024 Svitlana Rybalko, Oksana Poronnik, Ganna Myryuta, Anatoliy Balanda, Maryna Arkhypova, Daria Starosyla, Oleg Deryabin, Anton Puhovkin, Ivan Parnikoza, Viktor Kunakh